City of Hope Chicago is a comprehensive cancer treatment hospital located in Zion, Illinois, midway between Chicago and Milwaukee. At our Chicago hospital, experienced doctors, Magnet®-recognized nurses and other clinicians work together in one location, providing integrative cancer treatment tailored to each patient’s needs, preferences and goals.

Cancer Treatment Centers of America® (CTCA) is now City of Hope, joining forces to expand patient access to personalized, comprehensive cancer care.

Note: The driving directions provided by Google Maps and MapQuest can be confusing, as IL-37/Buckley Road may also be referred to as IL-137/Barron Road. Please use this directions link to get accurate directions from your location.

42.4490303, -87.8278042

2520 Elisha Avenue
Zion, IL 60099
New Patients
Current Patients

7 a.m. - 5 p.m. daily
24-Hour Access for Patients and Caregivers


Visitor Policy
  • Clinical Services
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At City of Hope Chicago, our experienced cancer experts are committed to delivering comprehensive, integrative care, all in one location. Their close collaboration allows our doctors and clinicians to share their knowledge, coordinate treatments and provide multidisciplinary cancer care tailored to each individual patient.

Our team is available 24 hours a day, every day of the year, to listen, answer your questions and help you decide on a treatment plan that’s right for you. 

At City of Hope Chicago, you'll find innovative treatments and technologies—all under one roof. Our cancer experts use state-of-the-art diagnostic tools, including advanced genomic testing, as well as leading technology to treat all types of cancer with the urgency and expertise it deserves.

Outpatient Care Centers

In keeping with the patient-centered approach at the heart of our care model, our Chicago-area Outpatient Care Centers in Downtown Chicago and Gurnee offer consultations, treatments and other cancer care services in convenient outpatient settings. These services are delivered by a team of experts who work closely with one another to understand each patient’s individual diagnosis and needs. We discuss available treatment options and side-effect management techniques with patients and their caregivers to help them decide on an integrative treatment plan tailored specifically to them, with a commitment to quality and speed to care. Both locations work closely with our Chicago hospital to provide a wider array of diagnostics, treatments and services not suitable for an outpatient setting. Read below to learn more about our Chicago-area centers.

Downtown Chicago

Located in the heart of the city, in the Streeterville neighborhood, City of Hope Downtown Chicago offers patients in and around Chicago convenient access to personalized cancer care and state-of-the-art technologies, such as the CyberKnife® radiosurgery system. 

City of Hope Downtown Chicago 


Located in Lake County, Illinois, City of Hope Gurnee offers patients in northern Illinois and southeastern Wisconsin convenient outpatient access to medical oncology, hematology and infusion services.

City of Hope Gurnee

Cancer Centers

Our cancer experts understand the value of focusing on one specific cancer type. That’s why we created our City of Hope Chicago cancer centers. These intensive programs bring together multidisciplinary teams of doctors and other clinicians with expertise in treating specific cancer types. The expert clinicians in our cancer centers collaborate daily, delivering comprehensive, personalized treatments tailored to each patient’s individual needs and goals. Read below to learn more about our Chicago cancer centers.

Breast Cancer Center

With so many treatment options available, breast cancer patients face many decisions. Because the experts at the Breast Cancer Center at City of Hope Chicago focus specifically on breast cancer, they have the experience to help you navigate the complexities of choosing a treatment plan tailored to your needs. With years of advanced training, our oncologists and other clinicians have expertise with the broad spectrum of diseases involved, including triple-negative breast cancer and inflammatory breast cancer.

Our Breast Cancer Center

GI Cancer Center

The clinicians at our GI Cancer Center in Chicago are committed to offering state-of-the-art treatments for patients with gastrointestinal cancer. Our multidisciplinary team of board-certified medical oncologists, surgical oncologists, radiation oncologists and supportive care clinicians works with our patients to deliver quality clinical care with a patient-centered approach. After your diagnosis, your GI Cancer Center care team will discuss your options with you and help you develop a personalized care plan tailored to your individual needs, preferences and goals.

Our GI Cancer Center

Gynecologic Cancer Center

The Gynecologic Cancer Center at City of Hope Chicago focuses on treating women with cancer of the reproductive organs. These cancers require not only expert care, but supportive services designed to help women stay strong during treatment and to address sexual and other side effects that may be a result of the disease or its treatment. The oncologists and other cancer experts at our Gynecologic Cancer Center work closely with behavioral health, oncology rehabilitation, nutritional support and other supportive care providers to help ease and prevent cancer-related side effects, such as lymphedema and pelvic floor weakness.

Our Gynecological Cancer Center

Lung Cancer Center

At the Lung Cancer Center at City of Hope Chicago, our singular focus enables our oncologists to stay up to date on new and emerging treatments and technologies, allowing us to help you make informed decisions about the options available to treat not just the disease but the side effects that may result. Clinical trials in immunotherapy, cryotherapy and other areas of innovation may be among the options available. Having a team of lung cancer experts collaborating daily, all under one roof, allows us to assemble a detailed treatment plan more quickly and more efficiently.

Our Lung Cancer Center

Women’s Cancer Center

At City of Hope Chicago, we understand the unique nature of cancers that are unique to women. That’s why we created the Women’s Cancer Center. Our experienced doctors and clinicians are singularly focused on screening, diagnosing and treating breast cancer and gynecologic cancers with a sense of urgency. Our supportive care services are designed to help address symptoms and side effects, to help you have the strength and stamina to stick with your treatment regimen and the quality of life to help you continue everyday activities throughout your cancer journey.

Our Women’s Cancer Center

We Make Getting Here Easy and Affordable

At City of Hope Chicago, we understand the stress and expense that comes with traveling for treatment. That’s why we make it our priority to see that your treatment is as convenient, affordable and stress-free as possible. One of the ways we do that is by paying certain travel costs for qualified patients* and their caregivers, and hosting their stay in local hotels at deeply reduced rates.

Before Your Visit

Prior to your visit, a City of Hope representative will:

  • Verify your insurance benefits
  • Obtain your medical records and transfer them to your hospital
  • Schedule your initial appointment
  • Schedule your air or train travel*
  • Reserve your accommodations at our on-site guest quarters or at a nearby hotel, at discounted rates
  • Greet you at the airport or train station and bring you to the hospital, or to your nearby lodging site*

COVID-19 Protocols and Safety Measures

Before you arrive, review the steps we’re taking to keep you, your caregiver and our staff safe as the pandemic continues to have implications for cancer patients.

Once You Arrive

Our hospital provides:

  • Concierge services (an information station at the hospital)
  • Healthy meal options by a world-class culinary team
  • Shuttle service to the airport*, local restaurants, shops and attractions
  • Fitness facility for you and your caregivers (at select facilities)
  • Patient and caregiver activities, classes and support groups
  • An on-site pharmacy/supplement center
  • Free wi-fi throughout the hospital


When you arrive at our hospital, our experienced travel and accommodations staff will work to help make your stay as pleasant as possible. If you are visiting from out of town, a member of our team will work with you prior to your arrival to help arrange affordable lodging. For qualifying patients and caregivers visiting City of Hope Chicago, we offer accommodations in our own guest rooms, either on-site or close to the hospital.

If available, our on-site accommodations may be offered at reduced rates. These comfortable rooms come with a variety of amenities designed to make you feel at home. While we would like to accommodate all our patients in our on-site guest rooms, these rooms are typically reserved for patients with special needs and those undergoing special treatments, so availability is limited.

We also partner with hotels near our facilities to offer quality accommodations and service at negotiated rates. Some of our partner hotels also provide special gathering rooms just for our patients and their caregivers. Due to the limitations of federal law, however, we are not permitted to provide travel, lodging or transportation benefits to Medicare patients or other patients whose health care is paid for by government insurance.


Lori’s Gifts: If you’re looking for a thoughtful gift for your loved one but aren’t able to visit our shop in person, Lori’s Gifts offers a wide variety of snacks, magazines, balloons, stuffed animals, toiletries and more. We offer free same-day delivery to patient rooms. Lori’s Gifts, located at City of Hope Chicago, is open Monday through Friday from 8 a.m. to 7 p.m., Saturday from 10 a.m. to 2 p.m. and closed on Sunday. During regular business hours, you can place an order by calling our direct line at 847-872-6396.

Cancer Fighters: When you need extra support or want to hear how others have endured similar situations, the Cancer Fighters® program is there for you. Created by our patients in 1990, this community offers you the opportunity to tap into the experiences from members across the country. Cancer Fighters members are patients, caregivers, friends and family—anyone looking to connect around the idea that no one should fight cancer alone.

Activities and Classes: We offer a variety of activities and classes to help you relax, enjoy your stay and meet new people who are going through a similar experience. Events vary by season, but they often include arts and crafts, sewing or cooking classes and visits from therapy dogs. Transportation may be available for off-site activities for qualifying patients.

Guest Services: Our guest services or concierge team welcomes you to our hospitals and provides a variety of services to help you during your visit.Guest services representatives may help with luggage and coats, check your travel and transportation information, provide information on patient activities and help direct you to local shopping and other locations and attractions.

* If you are a beneficiary of a government health insurance program, such as Medicare, City of Hope Chicago is not permitted to provide travel, lodging or transportation benefits.

** Meal costs for patients and caregivers vary.

Visitor Maps

Note: The driving directions provided by Google Maps and MapQuest can be confusing, as IL-37/Buckley Road may also be referred to as IL-137/Barron Road. Please use this directions link to get accurate directions from your location.

Get the Personalized Care You Deserve

One call to our team handles the details: insurance verification and appointment scheduling, whether you’re seeking a second opinion or a first-time diagnosis. We also help coordinate your travel and lodging arrangements, to make your visit as convenient and stress-free as possible. Learn the City of Hope Chicago difference

Two visitors receiving help at Guest Services desk

Need Help?

We’re here for you, contact us and we’ll answer any questions.